Clinical reactions and serologic changes after the administration of heterologous antilymphocyte globulin to human recipients of renal homografts.

Clinical reactions and serologic in all cases, to alpha globulins in 9 cases, and to SuMM*~y changes after intramuscular adgamma globulins in only 1. This h d i n g indicates ministration of horse anti-human lymphocyte that a safer ALG could be made by removing the globulin (ALG) were studied in 53 human retrace quantities of alpha and beta globulins from cipients of renal homografts. The ALG was used the immunologically more active gamma globuas an adjuvant immunosuppressive drug. In the lins. usual case 47 injections were given over a 4-month period. All patients had pain, tenderness, erythema, D URING THE LAST 14 MONTHS more than and swelling at the injection sites. Benign systemic 2,000 intramuscular injections of side effects included fever in all cases, hives in horse anti-human lymphocyte globulin eight cases, rash in five, pruritus in five, arthralgia in three, and periorbital edema in one. Anaphy(ALG) have been given to 53 Of